但这种垄断格局，即将被打破，多款在研新药正从作用机制到给药方式，向Vosoritide发起挑战。Ascendis的TransCon-CNP通过包裹技术延长了药物作用时间，实现了周剂给药，目前正处于FDA审批阶段；而BridgeBio的口服药Infigratinib，则从作用机制到用药体验实现全面突破。
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具体到单个项目，基金会的支持也很精准：比如Sun Health基金会投入1180万美元，帮Banner Boswell建成混合手术室；最近又提供472万美元，用于设备采购和患者护理；2023-2024年，还拿出9万美元作为护理奖学金，助力护士的教育和招聘。